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Elevated Levels of Anti-CD9 Antibodies in the Cerebrospinal Fluid of Patients with Subacute Sclerosing Panencephalitis.
- Source :
- Journal of Infectious Diseases; 5/1/2002, Vol. 185 Issue 9, p1346, 5p
- Publication Year :
- 2002
-
Abstract
- Subacute sclerosing panencephalitis (SSPE) is a slowly progressive and highly lethal disease of the central nervous system. Although the primary cause of SSPE is believed to be persistent infection of neuron and glial cells by a measles virus, the precise mechanism of the progression of this disease has not yet been elucidated. CD9, a member of the tetraspanin family, is expressed in myelin and other nervous tissues. This study detected significant amounts of anti-CD9 antibodies in the cerebrospinal fluid (CSF) of all patients with SSPE included in the study. Anti-CD9 antibodies were also detected in the CSF of some patients with other neurologic disorders, but those patients had lower levels of anti-CD9 antibodies than did the patients with SSPE. The level of anti-CD9 antibodies was elevated and reached a peak that coincided with the appearance of brain atrophy. These findings shed light on a new aspect of the causes and progression of SSPE. [ABSTRACT FROM AUTHOR]
- Subjects :
- SUBACUTE sclerosing panencephalitis
CEREBROSPINAL fluid
IMMUNOGLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 185
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 6587057
- Full Text :
- https://doi.org/10.1086/340134