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Chromosome 11 allele loss in sporadic insulinoma.

Authors :
Patel, P
O'Rahilly, S
Buckle, V
Nakamura, Y
Turner, R C
Wainscoat, J S
Source :
Journal of Clinical Pathology; May1990, Vol. 43 Issue 5, p377-378, 2p, 1 Black and White Photograph, 1 Chart
Publication Year :
1990

Abstract

DNA was extracted from tissue samples of three unrelated cases of insulinoma. Chromosome 11 allele loss was investigated using several chromosome 11 specific probes which detect restriction fragment length polymorphisms. In one case, which proved informative for many of the chromosome 11 markers, allele loss was shown on both 11p and 11q. This finding is of considerable interest as the allele loss closely corresponds to that recently reported in insulinomas occurring in the familial multiple endocrine neoplasia type 1 (MEN-1) syndrome. [ABSTRACT FROM PUBLISHER]

Details

Language :
English
ISSN :
00219746
Volume :
43
Issue :
5
Database :
Complementary Index
Journal :
Journal of Clinical Pathology
Publication Type :
Academic Journal
Accession number :
66085409
Full Text :
https://doi.org/10.1136/jcp.43.5.377