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High Salt Intake Accelerated Cardiac Remodeling in Spontaneously Hypertensive Rats: Time Window of Left Ventricular Functional Transition and Its Relation to Salt-Loading Doses.
- Source :
- Clinical & Experimental Hypertension; Nov2011, Vol. 33 Issue 7, p492-499, 8p
- Publication Year :
- 2011
-
Abstract
- Salt-loading is an accelerator of hypertensive left ventricular (LV) remodeling. The relationship between salt-loading doses and the time window in which a transition from compensated to decompensated LV hypertrophy occurs in spontaneously hypertensive rats (SHR) is unclear. Eight-week-old male SHR and Wistar Kyoto rats (WKY) were randomized to receive normal (0.5%% NaCl) and high salt diets (4%% or 8%% NaCl) for 12 weeks. Left ventricular remodeling was dynamically determined by echocardiography. LV invasive hemodynamics and morphologic staining [collagen deposition, cardiomyocte hypertrophy, DNA damage (8-hydroxy-2-deoxyguanosine, 8-OHdG) and apoptosis] were performed at time of sacrifice. Cardiac malonyldialdehyde (MDA) level was measured by ELISA. No differences between 4%% and 8%% salt diets, in terms of blood pressure (BP) levels, heart mass index, and myocardial fibrosis were observed either in SHR or in WKY. In high salt-loaded SHR, the LV ejection fraction and wall thickness peaked at 8 weeks after salt-loading, parallel with a progressive enlargement of the LV chamber size. Furthermore, when compared to 4%% salt SHR, LV functions were significantly compromised in 8%% salt SHR, accompanied by more prominent cardiomyoctye hypertrophy, oxidative stress (and related DNA damage), and apoptosis. Salt-loading for 12 weeks with 8%% NaCl diet is more efficient to induce LV dysfunction than 4%% NaCl diet does in SHR, possibly by initiating increased oxidative stress and resultant cardiac damage. Moreover, 8 to 12 weeks after 8%% salt-loading is the key time window in which a transition from compensated to decompensated LV hypertrophy occurs. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10641963
- Volume :
- 33
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Clinical & Experimental Hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 66358090
- Full Text :
- https://doi.org/10.3109/10641963.2010.551795