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Advanced glycation urinary protein-bound biomarkers and severity of diabetic nephropathy in man.
- Source :
- American Journal of Nephrology; 2011, Vol. 34 Issue 4, p347-355, 9p, 2 Charts, 3 Graphs
- Publication Year :
- 2011
-
Abstract
- <bold>Background/aims: </bold>The formation of advanced glycation end products (AGEs) is accelerated in patients with diabetic nephropathy. The aim of this study was to ascertain if the urinary excretion of proteins modified by advanced glycation can be used as biomarkers for albuminuria in individuals with type 1 or type 2 diabetes.<bold>Methods: </bold>Community-based patients with type 1 (n = 68) or type 2 diabetes (n = 216) attending a diabetes clinic of a tertiary referral hospital were classified as having normoalbuminuria (Normo, albumin excretion rate (AER) <20 μg/min), microalbuminuria (Micro, AER 20-200 μg/min) or macroalbuminuria (Macro, AER ≥200 μg/min). Serum and urine AGE-modified proteins were measured.<bold>Results: </bold>In patients with both type 1 diabetes and type 2 diabetes, there was a clear association between the degree of albuminuria and urinary AGE-modified proteins (p < 0.0001). Exclusive to patients with type 1 diabetes, urinary excretion of the AGE carboxymethyllysine correlated with AER, whereas patients with type 2 diabetes and macroalbuminuria had an increase in urinary methylglyoxal, an AGE intermediate. These changes were independent of isotopic glomerular filtration rate levels. Serum concentrations of AGEs or soluble receptor for AGEs were not consistently associated with albuminuria in either type 1 or type 2 diabetes.<bold>Conclusions: </bold>Urinary excretion of proteins modified by AGEs may be useful biomarkers of albuminuria in individuals with type 1 and type 2 diabetes, warranting prospective investigation in larger diabetic cohorts. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALBUMINURIA
COMPARATIVE studies
DIABETIC nephropathies
ENZYME-linked immunosorbent assay
GLOMERULAR filtration rate
TYPE 1 diabetes
LONGITUDINAL method
RESEARCH methodology
MEDICAL cooperation
TYPE 2 diabetes
ORGANIC compounds
RESEARCH
RESEARCH funding
OXIDATIVE stress
EVALUATION research
BODY mass index
Subjects
Details
- Language :
- English
- ISSN :
- 02508095
- Volume :
- 34
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- American Journal of Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 66799091
- Full Text :
- https://doi.org/10.1159/000331064