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CHD5 Downregulation Associated with Poor Prognosis in Epithelial Ovarian Cancer.
- Source :
- Gynecologic & Obstetric Investigation; Oct2011, Vol. 72 Issue 3, p203-207, 5p, 3 Charts, 3 Graphs
- Publication Year :
- 2011
-
Abstract
- Background: The CHD5 gene located on 1p36 encodes a protein - chromodomain helicase DNA-binding protein 5. CHD5 has been shown to be a tumor suppressor gene candidate. This study investigated the involvement of CHD5 in ovarian cancer and its clinicopathological significance. Methods: CHD5 expression in ovarian cancer and its counterpart were determined by quantitative RT-PCR. The correlation of CHD5 expression to clinicopathological features of the tumor was analyzed. Results: CHD5 expression was downregulated by at least twofold in 32 of 72 (41%) invasive epithelial ovarian carcinomas when compared to 12 controls in Hong Kong Chinese women. CHD5 downregulation was correlated to clinical status (p < 0.05), but not to patient age, tumor type and grade, recurrence and clinical stage (p > 0.05). Survival analysis showed that patients with CHD5 downregulation in their tumors were associated with shorter disease-free and total survival times compared to those without CHD5 downregulation (p < 0.05). Cox proportional-hazards regression analysis indicated that downregulation of CHD5 is an independent adverse prognostic factor in ovarian cancer. Conclusion: This study shows that CHD5 is downregulated in a certain number of ovarian cancers and appears to be an adverse predictor candidate of ovarian cancer disease-free and total survival. Copyright © 2011 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- DNA-binding proteins
OVARIAN cancer
CANCER genetics
EPITHELIUM
Subjects
Details
- Language :
- English
- ISSN :
- 03787346
- Volume :
- 72
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Gynecologic & Obstetric Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 66907306
- Full Text :
- https://doi.org/10.1159/000323883