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Upregulation of Micro RNA-146a (miRNA-146a), A Marker for Inflammatory Neurodegeneration, in Sporadic Creutzfeldt–Jakob Disease (sCJD) and Gerstmann–Straussler–Scheinker (GSS) Syndrome.
- Source :
- Journal of Toxicology & Environmental Health: Part A; Nov2011, Vol. 74 Issue 22-24, p1460-1468, 9p, 1 Diagram, 1 Graph
- Publication Year :
- 2011
-
Abstract
- A mouse- and human-brain-abundant, nuclear factor (NF)-кB-regulated, micro RNA-146a (miRNA-146a) is an important modulator of the innate immune response and inflammatory signaling in specific immunological and brain cell types. Levels of miRNA-146a are induced in human brain cells challenged with at least five different species of single- or double-stranded DNA or RNA neurotrophic viruses, suggesting a broad role for miRNA-146a in the brain's innate immune response and antiviral immunity. Upregulated miRNA-146a is also observed in pro-inflammatory cytokine-, Aβ42 peptide- and neurotoxic metal-induced, oxidatively stressed human neuronal-glial primary cell cocultures, in murine scrapie and in Alzheimer's disease (AD) brain. In AD, miRNA-146a levels are found to progressively increase with disease severity and co-localize to brain regions enriched in inflammatory neuropathology. This study provides evidence of upregulation of miRNA-146a in extremely rare (incidence 1–10 per 100 million) human prion-based neurodegenerative disorders, including sporadic Creutzfeldt–Jakob disease (sCJD) and Gerstmann–Straussler–Scheinker syndrome (GSS). The findings suggest that an upregulated miRNA-146a may be integral to innate immune or inflammatory brain cell responses in prion-mediated infections and to progressive and irreversible neurodegeneration of both the murine and human brain. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15287394
- Volume :
- 74
- Issue :
- 22-24
- Database :
- Complementary Index
- Journal :
- Journal of Toxicology & Environmental Health: Part A
- Publication Type :
- Academic Journal
- Accession number :
- 67039876
- Full Text :
- https://doi.org/10.1080/15287394.2011.618973