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Current understanding of hepatic and intestinal OATP-mediated drug--drug interactions.
- Source :
- Expert Review of Clinical Pharmacology; 2011, Vol. 4 Issue 6, p729-742, 14p
- Publication Year :
- 2011
-
Abstract
- At present, many patients are medicated with various drugs, which are, at the same time, associated with an increased risk of drug--drug interactions (DDIs). Detailed analysis of mechanisms underlying DDIs is the basis of a better prediction of adverse drug events caused by drug interactions. In the last few decades, an involvement of transporters in such processes has been more and more recognized. Indeed, uptake transporters belonging to the organic anion-transporting polypeptide (OATP) family have been shown to interact with a variety of drugs in clinical use. Particularly, the subfamily of OATP1B transporters has been extensively studied, identifying several clinical significant DDIs based on those hepatic uptake transporters. By contrast, the role of OATP2B1 in this context is rather underestimated. Therefore, in addition to known interactions based on OATP1B transporters, we have focused on DDIs probably based on OATP2B1 inhibition in the liver and those possibly owing to the inhibition of OATP2B1-mediated drug absorption in the intestine. [ABSTRACT FROM AUTHOR]
- Subjects :
- DRUG interactions
DRUG side effects
ANIONS
ABSORPTION (Physiology)
INTESTINES
Subjects
Details
- Language :
- English
- ISSN :
- 17512433
- Volume :
- 4
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Expert Review of Clinical Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 67120478
- Full Text :
- https://doi.org/10.1586/ecp.11.58