NKCC1 as an Epigenetically Regulated Transporter Involved in Blood Pressure Elevation With Age.

In this article, the author reflects on the study by H. A. Lee and colleagues on the increases methylation of Na⁺,K⁺,2Cl^- contransporter (Nkcc1) promoter in rats. He states that the data of the study suggest that maintaining hypomethylation in Nkcc1 promoter lies the development of hypertension. Furthermore, he notes that adenosine monophosphate-raising vasodilators inhibit the vascular smooth muscle cells (VSMC) NKCC1.