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CD83-stimulated monocytes suppress T-cell immune responses through production of prostaglandin E2.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; 11/15/2011, Vol. 108 Issue 46, p18778-18783, 6p
- Publication Year :
- 2011
-
Abstract
- CD83 is commonly known as a specific marker for mature dendritic cells. It has been shown to be important for CD4<superscript>+</superscript> T-cell development in the thymus. However, its function in the peripheral immune system remains enigmatic. Here, we show that CD83 inhibits proliferation and production of IL-2 and IFN-γ by T cells, and the inhibitory effect of CD83 is mediated by monocytes. Prostaglandin E2 (PGE<subscript>2</subscript>), but not IL-10 or TGF-β, was up-regulated specifically by CD83 in monocytes. Consistent with high levels of PGE<subscript>2</subscript>, expression of COX-2 also was increased upon CD83 treatment. NF-κB activation also is required for induction of PGE<subscript>2</subscript> by CD83. Finally, application of the COX-2-selective inhibitor NS-398 fully prevented CD83-triggered inhibition of T-cell responses. Our study establishes an immune-regulatory mechanism by CD83 via stimulation of PGE<subscript>2</subscript> production in monocytes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 108
- Issue :
- 46
- Database :
- Complementary Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 67434238
- Full Text :
- https://doi.org/10.1073/pnas.1018994108