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Two new indole alkaloids, 2-(3,3-dimethylprop-1-ene)-costaclavine and 2-(3,3-dimethylprop-1-ene)-epicostaclavine, from the marine-derived fungus Aspergillus fumigatus.
- Source :
- Journal of Natural Medicines; Jan2012, Vol. 66 Issue 1, p222-226, 5p
- Publication Year :
- 2012
-
Abstract
- Two new indole alkaloids, 2-(3,3-dimethylprop-1-ene)-costaclavine ( 1) and 2-(3,3-dimethylprop-1-ene)-epicostaclavine ( 2), together with the known compounds costaclavine ( 3), fumgaclavine A ( 4) and C ( 5), were isolated from the marine-derived fungus Aspergillus fumigatus. The planar structures of the two new compounds were elucidated on the basis of chemical and physicochemical evidence including MS, UV, IR and NMR spectra. Their stereochemistry was studied by NOESY, H-H coupling constant and CD spectra. The compounds 1, 2, 3 and 5 showed weak cytotoxicity against a mouse leukemia cell line (P388). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13403443
- Volume :
- 66
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Natural Medicines
- Publication Type :
- Academic Journal
- Accession number :
- 67684838
- Full Text :
- https://doi.org/10.1007/s11418-011-0565-3