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Expression of CD64 (FcγRI) in skin of patients with acute GVHD.
- Source :
- Bone Marrow Transplantation; Dec2011, Vol. 46 Issue 12, p1566-1569, 4p, 2 Color Photographs, 1 Chart
- Publication Year :
- 2011
-
Abstract
- GVHD remains a major problem in allo-SCT. We explored the presence of APC in skin biopsies of GVHD patients, using the IgG receptor CD64 expression as a hallmark for activated APC. By immunohistochemistry we demonstrated CD64 to be upregulated on host APC in skin biopsies of patients with acute GVHD and, less prominently, in chronic GVHD. Double staining for CD32 polymorphism revealed CD64-positive cells to be mainly of host origin. The majority of CD64-positive cells coexpressed CD68, indicating a macrophage phenotype. Given its very restricted cellular distribution, CD64 may represent an excellent target for APC-directed therapies in GVHD. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNOHISTOCHEMISTRY
GENETIC polymorphisms
PHENOTYPES
MACROPHAGES
BIOPSY
Subjects
Details
- Language :
- English
- ISSN :
- 02683369
- Volume :
- 46
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Bone Marrow Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 67699004
- Full Text :
- https://doi.org/10.1038/bmt.2010.337