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Induction of HA-1-specific cytotoxic T-cell clones parallels the therapeutic effect of donor lymphocyte infusion.
- Source :
- British Journal of Haematology; Jun2002, Vol. 117 Issue 4, p935-939, 5p, 2 Graphs
- Publication Year :
- 2002
-
Abstract
- Summary. Donor lymphocyte infusions (DLI) can induce a graft-versus-leukaemia (GvL) reaction in patients with relapsed disease. However, the mechanisms involved in remission induction are not completely known. A patient with chemotherapy-refractory relapse 1 year after human leucocyte antigen (HLA)-identical, unrelated stem cell transplantation (SCT) for bcr/abl-positive common acute lymphoblastic leukaemia (ALL) received a DLI from the original donor, and achieved complete cytogenetic and molecular remission concomitantly with extensive graft-versus-host disease (GvHD). Seven CD8<superscript>+</superscript> , donor-derived, alloreactive T-cell clones were generated by stimulating post-DLI remission cells with the patient's pretransplant mature dendritic cells. The minor histocompatibility antigen (mHag) recognized by these T-cell clones was identified as HA-1, a mHag associated with acute GvHD after SCT. Our finding provides evidence of HA-1-associated GvL effects after DLI that paralleled the eradication of full-blown, chemotherapy-refractory ALL relapse after allogeneic SCT. [ABSTRACT FROM AUTHOR]
- Subjects :
- LYMPHOCYTES
LEUKEMIA
HISTOCOMPATIBILITY antigens
Subjects
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 117
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 6808158
- Full Text :
- https://doi.org/10.1046/j.1365-2141.2002.03536.x