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Dementia, renal failure, and brain aluminum.
- Source :
- Annals of Internal Medicine; May79, Vol. 90 Issue 5, p741-747, 7p, 2 Charts, 4 Graphs
- Publication Year :
- 1979
-
Abstract
- Dialysis dementia is a progressive and usually fatal neurologic syndrome occurring in patients on chronic hemodialysis. These patients may also have elevated levels of aluminum (Al+3) in the cerebral cortex. Possible relations between brain Al+3, increased Al+3 intake, and dementia were evaluated. Studies were done in seven groups of patients and five groups of experimental animals. In both normal dogs and rats and those with renal failure, oral Al+3 loading (Al[OH]3), resulted in significant increases of brain Al+3 (P less than 0.01). In patients with renal failure, who were neither demented nor treated with dialysis, brain Al+3 was more than seven times normal (P less than 0.01), whereas in patients with dialysis dementia, mean brain Al+3 was more than 15 times normal. However, the two groups were not significantly different. Brain Al+3 was also significantly elevated in patients who had either metastatic cancer or hepatic coma. Apparently brain Al+3 can be elevated as a consequence of Al+3 loading, renal failure, and abnormalities of the blood-brain barrier. It is most likely that dialysis dementia has multifactoral causation and is probably not caused by elevated brain content of Al+3 alone. [ABSTRACT FROM AUTHOR]
- Subjects :
- DEMENTIA
HEMODIALYSIS patients
PHYSIOLOGICAL effects of aluminum
TREATMENT of chronic kidney failure
BRAIN metabolism
ACUTE kidney failure
ALUMINUM
ALUMINUM hydroxide
ANIMAL experimentation
CEREBRAL cortex
CHRONIC kidney failure
COMPARATIVE studies
DOGS
ELECTROENCEPHALOGRAPHY
HEMODIALYSIS
HEPATIC encephalopathy
LIVER
RESEARCH methodology
MEDICAL cooperation
MUSCLES
RATS
RESEARCH
TUMORS
SUBSTANCE-induced psychoses
EVALUATION research
Subjects
Details
- Language :
- English
- ISSN :
- 00034819
- Volume :
- 90
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Annals of Internal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 6984331
- Full Text :
- https://doi.org/10.7326/0003-4819-90-5-741