Back to Search
Start Over
Clinical and cognitive characteristics of children with attention-deficit hyperactivity disorder, with and without copy number variants.
- Source :
- British Journal of Psychiatry; Nov2011, Vol. 199 Issue 5, p398-403, 6p
- Publication Year :
- 2011
-
Abstract
- <bold>Background: </bold>Submicroscopic, rare chromosomal copy number variants (CNVs) contribute to neurodevelopmental disorders but it is not known whether they define atypical clinical cases.<bold>Aims: </bold>To identify whether large, rare CNVs in attention-deficit hyperactivity disorder (ADHD) are confined to a distinct clinical subgroup.<bold>Method: </bold>A total of 567 children with ADHD aged 5-17 years were recruited from community clinics. Psychopathology was assessed using the Child and Adolescent Psychiatric Assessment. Large, rare CNVs (>500 kb, <1% frequency) were defined from single nucleotide polymorphism data.<bold>Results: </bold>Copy number variant carriers (13.6%) showed no differences from non-carriers in ADHD symptom severity, symptom type, comorbidity, developmental features, family history or pre-/perinatal markers. The only significant difference was a higher rate of intellectual disability (24% v. 9%, χ(2) = 15.5, P = 0.001). Most CNV carriers did not have intellectual disability.<bold>Conclusions: </bold>Large, rare CNVs are not restricted to an atypical form of ADHD but may be more highly enriched in children with cognitive problems. [ABSTRACT FROM AUTHOR]
- Subjects :
- NEURODEVELOPMENTAL treatment
ATTENTION-deficit hyperactivity disorder
CHROMOSOMES
PSYCHIATRIC research
CHILD psychiatry
CHILD psychology
MENTAL health
PATHOLOGICAL psychology
GENETICS
BLACK people
BLOOD pressure
CARDIOVASCULAR diseases
COMPARATIVE studies
ECHOCARDIOGRAPHY
LONGITUDINAL method
RESEARCH methodology
MEDICAL cooperation
PROGNOSIS
RESEARCH
RESEARCH funding
EVALUATION research
BODY mass index
DISEASE incidence
DISEASE progression
LEFT ventricular hypertrophy
DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 00071250
- Volume :
- 199
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- British Journal of Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 69927539
- Full Text :
- https://doi.org/10.1192/bjp.bp.111.092130