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Intravenous immunoglobulins as therapeutic agents.
- Source :
- Annals of Internal Medicine; Sep87, Vol. 107 Issue 3, p367-382, 16p
- Publication Year :
- 1987
-
Abstract
- Intravenous immunoglobulins are stable monomeric pooled human IgG preparations for therapeutic use. Three intravenous immunoglobulins licensed in the United States are generally therapeutically equivalent. Intravenous immunoglobulin is the preferred agent for replacement therapy for most patients with primary or secondary antibody immunodeficiency because of the rapidity and ease of giving large quantities of IgG, even by self-administration. Disadvantages of intravenous immunoglobulins include frequent (approximately 10%) but usually not serious side effects, the need for venous access (often difficult in infants and young children), and high cost. Intravenous immunoglobulins are also beneficial in the prevention of certain viral infections, such as cytomegalovirus pneumonia and varicella; they may also have a synergistic effect with antibiotics in certain bacterial diseases. Intravenous immunoglobulin has also been used successfully in the management of idiopathic thrombocytopenia purpura, Kawasaki disease, and certain autoimmune diseases. Intravenous immunoglobulin may also be of use in certain high-risk and premature newborns. [ABSTRACT FROM AUTHOR]
- Subjects :
- THERAPEUTIC use of immunoglobulins
IMMUNODEFICIENCY
THERAPEUTICS
BACTERIAL disease treatment
AUTOIMMUNE disease treatment
IMMUNOLOGICAL deficiency syndrome treatment
VIRAL disease treatment
ANIMAL experimentation
COMPARATIVE studies
IMMUNIZATION
IMMUNOGLOBULINS
INTRAVENOUS therapy
LYMPHOCYTIC leukemia
RESEARCH methodology
MEDICAL cooperation
MUCOCUTANEOUS lymph node syndrome
RESEARCH
EVALUATION research
Subjects
Details
- Language :
- English
- ISSN :
- 00034819
- Volume :
- 107
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Annals of Internal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 7031375
- Full Text :
- https://doi.org/10.7326/0003-4819-107-2-367