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ARK5 is associated with the invasive and metastatic potential of human breast cancer cells.
- Source :
- Journal of Cancer Research & Clinical Oncology; Feb2012, Vol. 138 Issue 2, p247-254, 8p
- Publication Year :
- 2012
-
Abstract
- Purpose: To investigate the effects of Akt/ARK5 pathways on the metastatic potential of human breast cancer cells. Materials and methods: The human ARK5 gene was transfected into MDA-MB-231 cells. Effects of ARK5 on MDA-MB-231 cells were investigated in vitro. The tumorigenicity and spontaneously metastatic capability regulated by ARK5 were determined using an orthotopic xenograft tumor model. Results: ARK5 enhanced the invasive and metastatic potential of MDA-MB-231 cells under regulation by Akt. The enhancement was associated with increasing MMP-2, MMP-9, and MT1-MMP expression. The results were further demonstrated by RNA interference experiment. In an in vivo study, we also demonstrated that ARK5-transfected breast cancer cells grew faster and had more pulmonary metastases than its parental counterparts. Conclusion: ARK5 led to a more invasive phenotype and metastatic potential in human breast cancer dependent on Akt. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01715216
- Volume :
- 138
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Cancer Research & Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 70326992
- Full Text :
- https://doi.org/10.1007/s00432-011-1102-1