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A Convenient Synthesis of Novel 2,8-Disubstituted Pyrido[3,4-b]pyrazines Possessing Biological Activity.
- Source :
- Synthesis; 2012, Vol. 44, p69-82, 14p
- Publication Year :
- 2012
-
Abstract
- A regioselective synthetic route to 2,8-disubstituted pyrido[3,4-b]pyrazines, by initial condensation reaction between suitable diaminopyridines and α-keto aldehydes equivalents, has been developed. Focusing on the functionalization on C-8, 2-aryl-8-bromo- and 8-amino-2-arylpyrido[3,4-b]pyrazines have been synthesized. Anilines, amides, and ureas have been introduced at the 8-position from key intermediates. 2,8-Disubstituted pyrido[3,4- b]pyrazines thus prepared were found to be of biological interest. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00397881
- Volume :
- 44
- Database :
- Complementary Index
- Journal :
- Synthesis
- Publication Type :
- Academic Journal
- Accession number :
- 70486680
- Full Text :
- https://doi.org/10.1055/s-0031-1289613