Interacting genetic factors controlling the antibody response against the H-2.2 specificity.

The antibody response against the H-2.2 specificity has been studied in three H-2strains, B10.D2, DBA/2, and BALB/c, and their hybrids (B10.D2 × DBA/2)F and (B10.D2 × BALB/c)F. The genetic control of the response appears to be complex: The three pure strains are responders, whereas both hybrids when immunized with C3H-HTG are nonresponders. Individual analysis of N3 offspring is compatible with the idea that, in this combination, an Ea-4 incompatibility between donor and immunized strain is necessary for the anti-H-2.2 response to occur. H-2 /H-2 hybrids (B10.BR × B10.D2)F or (B10.BR × DBA/2)F are responders when immunized with C57BL/10 ( H-2) but not with B10.A(2R) ( H-2), indicating that simultaneously recognized H-2 specificities are necessary for the anti-H-2.2 response. [ABSTRACT FROM AUTHOR]