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Polymorphism of minor histocompatibility genes in wild mice.
- Source :
- Immunogenetics; 1983, Vol. 17 Issue 6, p637-647, 11p
- Publication Year :
- 1983
-
Abstract
- H-2-restricted cytolytic T lymphocytes (CTL) were generated against H-1, H-3, and H-4 antigens and tested against target cells of F hybrids between wild mice and inbred H-2 mice. The congenic strain combinations for the CTL production were such that they tested one allele each at the H-1 and H-4 loci and four alleles at the H-3 locus. Most of the wild mice tested came from Southern Germany, but a few mice came from other European countries and Egypt and Israel. Virtually all wild mice typed as positive with CTL directed against H-3 and H-4 antigens; 32% of the F hybrids tested reacted with anti-H-1CTL and 9% reacted with anti-H-3 CTL. The positive results were not caused by cross-reaction with allogeneic H-2 antigens controlled by the major histocompatibility complex (Mhc) genes of the wild mice. At least some of the H-3 and H-4 antigens detected by the CTL in the F hybrid were not identical with antigens of the immunizing strains. These results suggest a relatively low degree of polymorphism of the tested minor H loci in wild mice and further support the notion that minor H loci are unrelated to the Mhc. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00937711
- Volume :
- 17
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Immunogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 70618572
- Full Text :
- https://doi.org/10.1007/BF00366131