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Biological effects of trilostane in vitro on oocyte maturation and fertilization in the hamster.
- Source :
- Experientia; Nov1984, Vol. 40 Issue 11, p1214-1217, 4p
- Publication Year :
- 1984
-
Abstract
- The effects of the inhibition of steroidogenesis by trilostane on oocyte maturation were examined by studying spontaneous maturation and fertilization in vitro. 10 M trilostane had no influence on the meiotic process, whether the oocytes were naked or not. At a concentration of 10 M and 10 M trilostane, low normal pronuclear formation and high polyspermy were found during in vitro fertilization. However, no retarded male pronuclear development could be detected in the trilostane-treated group. Thus, steroid producing activity within ova is apparently necessary to prevent multiple sperm penetration, but it has no effect on meiosis or the action of the so-called male pronucleus growth factor (MPGF). [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00144754
- Volume :
- 40
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Experientia
- Publication Type :
- Academic Journal
- Accession number :
- 70749869
- Full Text :
- https://doi.org/10.1007/BF01946649