Plasma insulin and free fatty acids in young people with postprandial glycosuria: Plasma insulin response in the cases with borderline glucose tolerance test.

Plasma immunoreactive insulin and free fatty acid (F.F.A.) responses to an oral glucose load were observed in young students with glycosuria and with glucose intolerance of a slight degree. - The groups with a diabetic or a borderline glucose tolerance test (G.T.T.) had a delayed and protracted plasma insulin and F.F.A. response. Both responses were significantly greater than in the control group. The result indicates that a sluggish but high rise and a delayed fall of plasma insulin during the glucose load is characteristic of chemical diabetics and this tendency is seen in the cases with a borderline G.T.T. - The subjects with oxyhyperglycemic G.T.T. also had an initial delay in the insulin response and the peak was distinctly higher than in the control, but the fall was sharp. This suggests that oxyhyperglycemia is one of the preceding states of diabetes. - The subjects with renal glycosuria, in the definition of Lawrence, had a high-normal G.T.T., but their insulin and F.F.A. responses showed no difference from those of the normal. [ABSTRACT FROM AUTHOR]