Back to Search
Start Over
Transfer of experimental autoimmune insulitis by spleen cells in mice.
- Source :
- Diabetologia; Dec1980, Vol. 19 Issue 6, p516-520, 5p
- Publication Year :
- 1980
-
Abstract
- We have tested whether experimental insulitis induced by multiple subdiabetogenic injections of streptozotocin can be transferred by lymphocytes to normal recipients. C57BL/6J mice were treated on 5 consecutive days with 40 mg streptozotocin /kg body weight. 5×10 nucleated spleen cells from 20 animals which had developed hyperglycaemia with concomitant insulitis three weeks after the first streptozotocin-injection, were transferred into congenic thymusless C57BL/6J-nu/nu mice. The cell transfer led to lymphocytic infiltrations of pancreatic islets in 75% of the recipients. Hyperglycaemia was not observed. It is concluded that lowdose streptozotocin treatment induces cellular immune reactions against pancreatic islets. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0012186X
- Volume :
- 19
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Diabetologia
- Publication Type :
- Academic Journal
- Accession number :
- 70806912
- Full Text :
- https://doi.org/10.1007/BF00253178