Single-dose intravesical Epodyl after TUR of Ta TCC bladder carcinoma.

Between 1973 and 1979, 130 patients with pT noninvasive bladder carcinoma were treated either by TUR plus intravesical chemotherapy with a single dose of Epodyl on the following day (60 patients), or by TUR only (70 patients). There was no significant difference between the two treatment groups as to time until first recurrence. However, the recurrence rate with Epodyl was significantly lower than that with no adjuvant treatment ( P<0.01). The incidence of increase in T-category was lower among patients who received Epodyl ( P<0.01). Thus single dose intravesical chemotherapy following TUR appeared to be beneficial. [ABSTRACT FROM AUTHOR]