Frank H. George Research Award winning paper Cancer self-remission and tumour instability – a cybernetic analysis Towards a fresh paradigm for cancer treatment.

Aims to investigate the causative factors and clinical applicability of spontaneous regression of malignant tumours without treatment, a really paradoxical phenomenon with many therapeutic potentialities. Analyses past cases to find that the commonest cause is a preceding episode of high fever-induced thermal fluctuation which produces fluctuation of biochemical/immunological parameters. Using Prigogine-Glansdorff-Langevin stability theory and biocybernetic principles, develops the theoretical foundation of a tumour's self-control, homeostasis and regression induced by thermal, radiation or oxygenation fluctuations. Derives a threshold condition of perturbations for producing regression. Presents some striking confirmation of such fluctuation-induced regression in Ewing tumour, Clear cell cancer and Lewis lung carcinoma. Using experimental data on patients, elucidates a novel therapeutic approach of multi-modal hyper-fluctuation utilizing radiotherapeutic hyper-fractionation, temperature and immune-status. [ABSTRACT FROM AUTHOR]