Einfluß von Prostaglandin E auf den Aminosäurestoffwechsel des menschlichen Skelettmuskels.

The influence of an intraarterial infusion of PGE on the amino acid metabolism of human sceletal muscle was examined in healthy volunteers using the forearm technique. A continuous increase of perfusion from 2.9±0.1 ml/100 g × min to 5.4±1.5 after 60 min could be observed. Muscular amino acid balances were not changed after 30 min but significantly after 60 min of PGE infusion. Muscular release of most of the amino acids was reduced or shifted to an uptake. The accumulated balance of the amino acids showed a significant increase from −21.9 to +33.2 nmol/ 100 g × min after 60 min. Thus the infusion of PGE led to an inhibition of muscular proteolysis and/or to a stimulation of proteosynthesis. In view of the fact that kinines are released during exercise and are partially effective via prostaglandine liberation, the protein-anabolic effect of exercise might be explained by action of prostaglandins. [ABSTRACT FROM AUTHOR]