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Rectal absorption of flecainide acetate.

Authors :
Lie-A-Huen, L.
Kingma, J.
Source :
European Journal of Clinical Pharmacology; 1988, Vol. 35 Issue 1, p89-91, 3p
Publication Year :
1988

Abstract

The rectal absorption of flecainide from an aqueous solution, a fatty suppository and a polyethyleneglycol suppository was studied in one patient with supraventricular tachycardia (Wolff-Parkinson-White syndrome) refractory for oral anti-arrhythmic treatment. Rectal absorption was found to be fast (t=1 h) and complete when flecainide was administered as a solution (relative bioavailability 100%). Flecainide was poorly absorbed from a fatty suppository. The polyethyleneglycol suppository gave absorption with a relative bioavailability of 80% and t=1.2 h. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00316970
Volume :
35
Issue :
1
Database :
Complementary Index
Journal :
European Journal of Clinical Pharmacology
Publication Type :
Academic Journal
Accession number :
72384750
Full Text :
https://doi.org/10.1007/BF00555514