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Chronic cobalt-induced epilepsy: Noradrenaline ionophoresis and adrenoceptor binding studies in the rat cerebral cortex.
- Source :
- Journal of Neural Transmission; 1985, Vol. 63 Issue 2, p109-118, 10p
- Publication Year :
- 1985
-
Abstract
- Several studies indicate that brain noradrenaline (NA) depletion facilitates the occurrence of epileptogenic syndromes in various animal models. In cobalt-induced epilepsy in the rat, seizure activity is associated with a cortical NA denervation. In order to search for cortical adrenoceptor modifications, inonophoretic studies and adrenoceptor binding assays were performed. At the period of maximal seizure activity, there was a significant supersensitivity of cortical neurons to the ionophoretic application of NA. An increase in the density of β-adrenoceptor binding sites was observed. No modification in α- and α-adrenoceptor binding sites was found. This suggests that in cobalt-induced epilepsy there is a denervation supersensitivity which rests on a selective involvement of β-adrenoceptors. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03009564
- Volume :
- 63
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Neural Transmission
- Publication Type :
- Academic Journal
- Accession number :
- 72485209
- Full Text :
- https://doi.org/10.1007/BF01252611