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Chronic cobalt-induced epilepsy: Noradrenaline ionophoresis and adrenoceptor binding studies in the rat cerebral cortex.

Authors :
Bregman, B.
Saux, F.
Trottier, S.
Chauvel, P.
Maurin, Y.
Source :
Journal of Neural Transmission; 1985, Vol. 63 Issue 2, p109-118, 10p
Publication Year :
1985

Abstract

Several studies indicate that brain noradrenaline (NA) depletion facilitates the occurrence of epileptogenic syndromes in various animal models. In cobalt-induced epilepsy in the rat, seizure activity is associated with a cortical NA denervation. In order to search for cortical adrenoceptor modifications, inonophoretic studies and adrenoceptor binding assays were performed. At the period of maximal seizure activity, there was a significant supersensitivity of cortical neurons to the ionophoretic application of NA. An increase in the density of β-adrenoceptor binding sites was observed. No modification in α- and α-adrenoceptor binding sites was found. This suggests that in cobalt-induced epilepsy there is a denervation supersensitivity which rests on a selective involvement of β-adrenoceptors. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03009564
Volume :
63
Issue :
2
Database :
Complementary Index
Journal :
Journal of Neural Transmission
Publication Type :
Academic Journal
Accession number :
72485209
Full Text :
https://doi.org/10.1007/BF01252611