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Activity of cefotiam in combination with beta-lactam antibiotics on enterobacterial hospital strains.
- Source :
- Pharmaceutisch Weekblad; 1990, Vol. 12 Issue 3, p104-106, 3p
- Publication Year :
- 1990
-
Abstract
- By using checkerboard titrations the effect of cefotiam combined with different beta-lactam antibiotics on fifty strains of Enterobacteriaceae moderately susceptible (minimal inhibiting concentration ⩾8 mg/l) or resistant (minimal inhibiting concentration ⩾64 mg/l) to cefotiam was evaluated. The following compounds were tested: cefamandole, cefazolin, cefmenoxime, cefotaxime, cefotiam, ceftazidime, cefuroxime, mecillinam and piperacillin. The synergistic effect varied markedly. The combination cefotiam-mecillinam showed the highest rate of synergistic activity. Antagonism was found in 1% of the combinations. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00316911
- Volume :
- 12
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Pharmaceutisch Weekblad
- Publication Type :
- Academic Journal
- Accession number :
- 72964524
- Full Text :
- https://doi.org/10.1007/BF01967603