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Inhibitory effect of cyclosporin A on T lymphocyte DNA synthesis.
- Source :
- Journal of Tongji Medical University; 1992, Vol. 12 Issue 1, p39-42, 4p
- Publication Year :
- 1992
-
Abstract
- The interference of Cyclosporin A (CyA) with peripheral lymphocytes DNA synthesis was investigated. The results showed that the drug could strongly inhibit T cell proliferation in response to PHA stimulation if added at the start or at the early phase of the process, and it failed to do so if added 48 h later when most cells had already started to proliferate. Without PHA, no obvious differences were detected between normal control and CyAtreated cells. A comparison was made between T cell DNA synthesis of peripheral blood lymphocytes of healthy volunteers and renal transplant patients. It was found that T-cell DNA synthesis of patients was significantly lower than that of the healthy controls. From the above it may be suggested that CyA activity on T cell proliferation is similar in vivo and in vitro. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0257716X
- Volume :
- 12
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Tongji Medical University
- Publication Type :
- Academic Journal
- Accession number :
- 73008762
- Full Text :
- https://doi.org/10.1007/BF02887757