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NF-κB p65 phosphorylated at serine-536 is an independent prognostic factor in Swedish colorectal cancer patients.
- Source :
- International Journal of Colorectal Disease; Apr2012, Vol. 27 Issue 4, p447-452, 6p
- Publication Year :
- 2012
-
Abstract
- Introduction: The NF-κB transcription factor protein family has diverse cellular and biological functions, and posttranslational modification is important to regulate these functions. An important site of phosphorylation of NF-κB p65 subunit is at serine-536 (phospho-Ser536-p65), and this phosphorylation is involved in regulation of transcriptional activity, nuclear localization, and protein stability. Patients and Methods: In this study, we investigated expression of phospho-Ser536-p65 in colorectal cancers and its relationships with clinicopathological factors. The expression of phospho-Ser536-p65 was examined by immunohistochemistry in 203 primary colorectal cancers, 156 normal mucosa specimens, and 18 metastases in the lymph nodes. Results: The expression of phospho-Ser536-p65 increased from normal mucosa to primary tumor ( p < 0.0001). Further, the increased expression of phospho-Ser536-p65 in the cytoplasm of the primary tumors correlated with worse survival of the patients independently of gender, age, tumor location, stage, and differentiation ( p = 0.04; hazard ratio, 1.89; 95% CI 1.03-3.47). Conclusion: The NF-κB p65 subunit phosphorylated at serine-536 is an independent prognostic factor in colorectal cancer patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- COLON cancer
IMMUNOHISTOCHEMISTRY
TRANSCRIPTION factors
PHOSPHORYLATION
LYMPH nodes
Subjects
Details
- Language :
- English
- ISSN :
- 01791958
- Volume :
- 27
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- International Journal of Colorectal Disease
- Publication Type :
- Academic Journal
- Accession number :
- 73499343
- Full Text :
- https://doi.org/10.1007/s00384-011-1356-8