Back to Search
Start Over
Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns.
- Source :
- Pediatric Allergy & Immunology; Mar2012, Vol. 23 Issue 2, p173-180, 8p, 1 Chart, 3 Graphs
- Publication Year :
- 2012
-
Abstract
- To cite this article: Lisciandro JG, Prescott SL, Nadal-Sims MG, Devitt CJ, Pomat W, Siba PM., Holt PG, Strickland D, van den Biggelaar AHJ. Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns. Pediatr Allergy Immunol 2011: Doi: 10.1111/j.1399-3038.2011.01242.x. Abstract Background: Environmental changes, including declining microbial exposure, have been linked with the rising incidence of allergic and autoimmune diseases in 'western' populations. This potentially occurs by altering early development of immuno-regulatory pathways including T regulatory cells (T<subscript>reg</subscript>). There is now increasing evidence that such conditioning begins in utero. Methods: We compared neonatal T<subscript>reg</subscript> from children born under typical western conditions (Australia, AUS) with those of neonates born under more traditional conditions of high microbial burden (Papua New Guinea, PNG). Results: The frequency of neonatal T<subscript>reg</subscript>, defined as CD4<superscript>+</superscript> Foxp3<superscript>+</superscript> CD127<superscript>−</superscript> CD25<superscript>+/high</superscript> was found to be higher in the cord blood of AUS compared to PNG newborns. However, cord T<subscript>reg</subscript> suppressive function in a small subset of children was qualitatively similar between PNG and AUS newborns in both a T<subscript>reg</subscript> depletion assay and a T<subscript>reg</subscript> supplementation assay. Conclusions: These findings do not support the hypothesis that living in a 'western' versus more traditional environment leads to poor induction or suppressive function of neonatal T<subscript>reg</subscript>. However, environmentally-induced immuno-regulation may potentially occur via alternative mechanisms in PNG newborns that should now be investigated further. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09056157
- Volume :
- 23
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Pediatric Allergy & Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 73522847
- Full Text :
- https://doi.org/10.1111/j.1399-3038.2011.01242.x