Back to Search
Start Over
Dynamic Ventilation ^3He MRI for the Quantification of Disease in the Rat Lung.
- Source :
- IEEE Transactions on Biomedical Engineering; Mar2012, Vol. 59 Issue 3, p777-786, 10p
- Publication Year :
- 2012
-
Abstract
- Pulmonary diseases are known to be largely inhomogeneous. To evaluate such inhomogeneities, we are testing an image-based method to measure gas flow in the lung regionally. Dynamic, spin-density-weighted hyperpolarized ^3He MR images performed during slow inhalation of this gas were analyzed to quantify regional inflation rate. This parameter was measured in regions of interest (ROIs) that were defined by a rectangular grid that covered the entire rat lung and grew dynamically with it during its inflation. We used regional inflation rate to quantify elastase-induced emphysema and to differentiate healthy ( n = 8) from elastase-treated ( n = 9) rat lungs as well as healthy from elastase-treated areas of one rat unilaterally treated with elastase in the left lung. Emphysema was also assessed by gold standard morphological and well-established hyperpolarized ^3He MRI diffusion measurements. Mean values of regional inflation rates were significantly different for healthy and elastase-treated animals and correlated well with the apparent diffusion coefficient of ^3He and morphological measurements. The image-based biomarker inflation rate may be useful for the assessment of regional lung ventilation. [ABSTRACT FROM PUBLISHER]
- Subjects :
- LUNG diseases
MAGNETIC resonance imaging
LUNGS
LABORATORY rats
LUNG physiology
Subjects
Details
- Language :
- English
- ISSN :
- 00189294
- Volume :
- 59
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- IEEE Transactions on Biomedical Engineering
- Publication Type :
- Academic Journal
- Accession number :
- 73612839
- Full Text :
- https://doi.org/10.1109/TBME.2011.2179299