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Hsa-miR-196a2 Rs11614913 Polymorphism Contributes to Cancer Susceptibility: Evidence from 15 Case-Control Studies.
- Source :
- PLoS ONE; 2011, Vol. 6 Issue 3, p1-6, 6p
- Publication Year :
- 2011
-
Abstract
- Background: MicroRNAs (miRNAs) are a family of endogenous, small and noncoding RNAs that negatively regulate gene expression by suppressing translation or degrading mRNAs. Recently, many studies investigated the association between hsa-miR-196a2 rs11614913 polymorphism and cancer risk, which showed inconclusive results. Methodology/Principal Findings: We conducted a meta-analysis of 15 studies that included 9,341 cancer cases and 10,569 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95% confidence intervals (CIs). Overall, individuals with the TC/CC genotypes were associated with higher cancer risk than those with the TT genotype (OR = 1.18, 95% CI = 1.03-1.34, P<0.001 for heterogeneity test). In the stratified analyses, we observed that the CC genotype might modulate breast cancer risk (OR = 1.11, 95%CI = 1.01-1.23, P<subscript>heterogeneity</subscript> = 0.210) and lung cancer risk (OR = 1.25, 95%CI = 1.06-1.46, P<subscript>heterogeneity</subscript> = 0.958), comparing with the TC/TT genotype. Moreover, a significantly increased risk was found among Asian populations in a dominant model (TC/CC versus TT, OR = 1.24, 95% CI = 1.07-1.43, P<subscript>heterogeneity</subscript> = 0.006). Conclusions: These findings supported that hsa-miR-196a2 rs11614913 polymorphism may contribute to the susceptibility of cancers. [ABSTRACT FROM AUTHOR]
- Subjects :
- GENETIC polymorphisms
CANCER risk factors
BREAST cancer
GENETIC regulation
RNA
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 6
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 73787344
- Full Text :
- https://doi.org/10.1371/journal.pone.0018108