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Sec14l3 Is Specifically Expressed in Mouse Airway Ciliated Cells.
- Source :
- Inflammation; Apr2012, Vol. 35 Issue 2, p702-712, 11p
- Publication Year :
- 2012
-
Abstract
- Airway epithelium is a key component for airway integrity. Previously, we found that expression of the Sec14l3 gene that encodes a 45-kDa secretory protein is inversely associated with the progression of experimentally induced airway inflammation and degeneration/necrosis of alveolar epithelium. In this report, using in situ hybridization we demonstrated that the ciliated cells in mouse lung selectively express Sec14l3 mRNA. In a three-dimensional culture of mouse tracheal epithelial cells, levels of the Sec14l3 mRNA correlated with the differentiation of ciliated cells. Intranasal infection of adult mice with influenza virus resulted in a 20-fold, progressive decrease in Sec14l3 mRNA expression over 10 days post infection. These results enhance the potential value of Sec14l3 as a ciliated epithelial cell-specific biomarker for the progression of airway inflammations such as airway viral infection and asthma. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03603997
- Volume :
- 35
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Inflammation
- Publication Type :
- Academic Journal
- Accession number :
- 73910065
- Full Text :
- https://doi.org/10.1007/s10753-011-9363-z