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Baicalin Down-regulates the Expression of Macrophage Migration Inhibitory Factor (MIF) Effectively for Rats with Ulcerative Colitis.
- Source :
- Phytotherapy Research; Apr2012, Vol. 26 Issue 4, p498-504, 7p
- Publication Year :
- 2012
-
Abstract
- The purpose of this study was to investigate whether baicalin, a Chinese herbal extract, down-regulates the expression of macrophage migration inhibitory factor (MIF), an inflammatory factor that regulates the function of macrophages (MΦ), in rats with trinitrobenzene sulphonic acid (TNBS)-induced ulcerative colitis (UC). The results showed that baicalin simultaneously down-regulated the expression of MIF, the quantity of MΦs and the amount of MΦ-related cytokines, including macrophage chemotactic factor-1 (MCP-1, CCL2) and macrophage inflammatory protein-3α (MIP-3α, CCL20), in rats with UC. There was no statistical difference between baicailin and mesalazine in down-regulating the expression of MIF. Our study demonstrated that baicalin, an inexpensive but effective monomer, could be a new and alternative pharmaceutical for UC. Copyright © 2011 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0951418X
- Volume :
- 26
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Phytotherapy Research
- Publication Type :
- Academic Journal
- Accession number :
- 74104626
- Full Text :
- https://doi.org/10.1002/ptr.3581