Easy Synthesis of Novel 4-Azolylpyridazin-3-ones.

Authors :: Geraschenko, Oleksandr V.
Khodakovskiy, Pavel V.
Shivanyuk, Oleksandr N.
Shishkin, Oleg V.
Mykhailiuk, Pavel K.
Tolmachev, Andrey A.
Source :: Synthesis; 2012, Vol. 44, p1263-1267, 5p
Publication Year :: 2012
Abstract: Ethyl azol-2-ylglyoxylates react smoothly with acetone in the presence of catalytic amounts of proline and trifluoroacetic acid to give the corresponding azolyl aldols in 93-98% yield. The products are easily transformed into azolyl pyridazinones in 85- 98% yield by cyclization with hydrazine hydrate. [ABSTRACT FROM AUTHOR]