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Peripheral Nervous System Function and Organophosphate Pesticide Use among Licensed Pesticide Applicators in the Agricultural Health Study.
- Source :
- Environmental Health Perspectives; Apr2012, Vol. 120 Issue 4, p515-520, 6p, 3 Charts
- Publication Year :
- 2012
-
Abstract
- Background: Evidence is limited that long-term human exposure to organophosphate (OP) pesticides, without poisoning, is associated with adverse peripheral nervous system (PNS) function. Objective: We investigated associations between OP pesticide use and PNS function by administering PNS tests to 701 male pesticide applicators in the Agricultural Health Study (AHS). Methods: Participants completed a neurological physical examination (NPx) and electrophysiological tests as well as tests of hand strength, sway speed, and vibrotactile threshold. Self-reported information on lifetime use of 16 OP pesticides was obtained from AHS interviews and a study questionnaire. Associations between pesticide use and measures of PNS function were estimated with linear and logistic regression controlling for age and outcome-specific covariates. Results: Significantly increased odds ratios (ORs) were observed for associations between ever use of 10 of the 16 OP pesticides and one or more of six NPx outcomes. Most notably, abnormal toe proprioception was significantly associated with ever use of 6 OP pesticides, with ORs ranging from 2.03 to 3.06; monotonic increases in strength of association with increasing use was observed for 3 of the 6 pesticides. Mostly null associations were observed between OP pesticide use and electrophysiological tests, hand strength, sway speed, and vibrotactile threshold. Conclusions: This study provides some evidence that long-term exposure to OP pesticides is associated with signs of impaired PNS function among pesticide applicators. [ABSTRACT FROM AUTHOR]
- Subjects :
- AGRICULTURAL laborers
CHI-squared test
CONFIDENCE intervals
ELECTROPHYSIOLOGY
EPIDEMIOLOGY
GRIP strength
LONGITUDINAL method
MEDICAL cooperation
PERIPHERAL nervous system
NEUROLOGIC examination
ORGANOPHOSPHORUS compounds
PESTICIDES
PROPRIOCEPTION
QUESTIONNAIRES
REGRESSION analysis
RESEARCH
RESEARCH funding
SELF-evaluation
LOGISTIC regression analysis
OCCUPATIONAL hazards
DATA analysis
ENVIRONMENTAL exposure
DATA analysis software
FUNCTIONAL assessment
DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 00916765
- Volume :
- 120
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Environmental Health Perspectives
- Publication Type :
- Academic Journal
- Accession number :
- 74530559
- Full Text :
- https://doi.org/10.1289/ehp.1103944