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Chronic kidney disease associated with perinatal HIV infection in children and adolescents.
- Source :
- Pediatric Nephrology; Jun2012, Vol. 27 Issue 6, p981-989, 9p, 3 Charts
- Publication Year :
- 2012
-
Abstract
- Background: This study describes the incidence, clinical and demographic characteristics, and spectrum of chronic kidney disease (CKD) in youths with perinatal HIV-1 infection. Methods: Retrospective analysis between May 1993 and December 2006 of subjects with renal disease followed in the Pediatric AIDS Clinical Trials Group 219/219C multicenter study examining the long-term consequences of perinatal HIV infection. Diagnosis confirmation was made utilizing a questionnaire mailed to research sites. Participants with CKD of other etiology than HIV were excluded. Outcome measures were biopsy-diagnosed CKD and, in the absence of biopsy, HIV-associated nephropathy (HIVAN) using established clinical criteria. Results: Questionnaires on 191 out of 2,102 participants identified 27 cases of CKD: 14 biopsy-diagnosed and 6 clinical cases of HIVAN, and 7 biopsy-diagnosed cases of immune complex-mediated kidney disease (lupus-like nephritis, 3; IgA nephropathy, 2; membranous nephropathy, 2). Incidence rates for CKD associated with HIV in pre-highly active antiretroviral therapy (HAART) (1993-1997) and HAART (1998-2002, 2003-2006) eras were 0.43, 2.84, and 2.79 events per 1,000 person years respectively. In multivariate analysis, black race and viral load ≥100,000 copies/mL (rate ratios 3.28 and 5.05, p ≤ 0.02) were associated with CKD. Conclusions: A variety of immune complex-mediated glomerulonephritides and HIVAN occurs in this population. Black race and uncontrolled viral replication are risk factors for CKD associated with HIV. [ABSTRACT FROM AUTHOR]
- Subjects :
- HIV infection epidemiology
AIDS complications
BLACK people
BLOOD cell count
CHI-squared test
CHRONIC kidney failure
CONFIDENCE intervals
FISHER exact test
KIDNEY diseases
MEDICAL cooperation
POISSON distribution
QUESTIONNAIRES
RACE
RESEARCH
RESEARCH funding
STATISTICS
T cells
T-test (Statistics)
WHITE people
DATA analysis
VIRAL load
MULTIPLE regression analysis
HIGHLY active antiretroviral therapy
DISEASE incidence
RETROSPECTIVE studies
DATA analysis software
DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 0931041X
- Volume :
- 27
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Pediatric Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 74574778
- Full Text :
- https://doi.org/10.1007/s00467-011-2097-1