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Molecular Mechanisms Linking Endometriosis Under Oxidative Stress With Ovarian Tumorigenesis and Therapeutic Modalities.
- Source :
- Cancer Investigation; Jul2012, Vol. 30 Issue 6, p473-480, 8p
- Publication Year :
- 2012
-
Abstract
- Inflammation plays a role in the pathogenesis of endometriosis. Endometriosis-associated ovarian carcinogenesis might be promoted through oxidative stress-induced increased genomic instability, aberrant methylation, and aberrant chromatin remodeling, as well as mutations of tumor suppressor genes. Aberrant expression of ARID1A, PIK3CA, and NF-kB genes has been recognized as the major target genes involved in oxidative stress-induced carcinogenesis. HNF-1beta appears to play a key role in anti-oxidative defense mechanisms. We discuss the pathophysiologic roles of oxidative stress as somatic mutations as well as highly specific agents that effectively modulate these targets. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07357907
- Volume :
- 30
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Cancer Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 76273889
- Full Text :
- https://doi.org/10.3109/07357907.2012.681821