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Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin
- Source :
- FEBS Letters; Jun2012, Vol. 586 Issue 13, p1813-1820, 8p
- Publication Year :
- 2012
-
Abstract
- Abstract: Epithelial-mesenchymal transition (EMT) has been shown to play a key role in embryogenesis and cancer progression. We previously found that fibronectin (FN) carrying O-GalNAc at a specific site is selectively expressed in cancer and fetal cells/tissues, and termed oncofetal FN (onfFN). Here, we show that (i) a newly-established monoclonal antibody against FN lacking the O-GalNAc, termed normalFN (norFN), is useful for isolation of onfFN, (ii) onfFN, but not norFN, can induce EMT in human lung carcinoma cells, (iii) onfFN has a synergistic effect with transforming growth factor (TGF)β1 in EMT induction. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 586
- Issue :
- 13
- Database :
- Complementary Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 76617945
- Full Text :
- https://doi.org/10.1016/j.febslet.2012.05.020