Optimization of Acylation of Quercetin Using Response Surface Methodology.

The optimization of acylation of quercetin was studied in this study. Through response surface methodology, the optimum condition was determined as following: molar ratio of quercetin to acetic anhydride 15, addition of pyridine drop 1.00, reaction temperature 45 °C and reaction time 106.59 min. Under this condition, the yield was as high as 0.3814 g with 0.32 g quercetin as raw material. [ABSTRACT FROM AUTHOR]