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In Vivo Evidence that the Increase in Matrix Metalloproteinase Activity Occurs Early after Cerebral Ischemia.
- Source :
- Molecular Imaging; Jan/Feb2012, Vol. 11 Issue 1, p22-26, 5p
- Publication Year :
- 2012
-
Abstract
- There is controversy over whether matrix metalloproteinases (MMPs) are activated during the early therapeutic window following ischemic stroke. Ex vivo, an increase was reported as early as 4 hours, whereas in vivo, no increase was found until 24 hours postischemia. We used fluorescence diffuse optical tomography to image MMP activity following experimental cerebral ischemia; increased MMP activity was observed in the ischemic area as early as 3 to 6 hours after ischemic onset and correlated with the volume of ischemic cerebral tissue. Therefore, MMP activation is an immediate early response to cerebral ischemia concurrent with the therapeutic window. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15353508
- Volume :
- 11
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Molecular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 76925095
- Full Text :
- https://doi.org/10.2310/7290.2011.00023