Back to Search
Start Over
Correlations of macronutrient-induced functional magnetic resonance imaging signal changes in human brain and gut hormone responses.
- Source :
- American Journal of Clinical Nutrition; Aug2012, Vol. 96 Issue 2, p275-282, 8p, 1 Black and White Photograph, 3 Charts, 1 Graph
- Publication Year :
- 2012
-
Abstract
- Background: Body energy homeostasis is largely regulated by the interactions between appetite-related brain regions and gut hormones. Objective: We hypothesized that the sensitivity of appetite-related brain regions [eg, hypothalamus, insula, thalamus, parahippocampal/ hippocampal cortex, caudate, putamen, amygdala, and orbitofrontal cortex (OFC)] varies for each macronutrient, and the differential sensitivity is associated with gut hormone concentrations in humans. Design: Brain activation responses to ingested fat, glucose, protein, and water in the above-mentioned 8 brain regions of 14 healthy men were investigated by using functional magnetic resonance imaging. Fasting and postprandial plasma glucose, insulin, ghrelin, cholecystokinin (CCK), and glucagon-like peptide 1 (GLP-1) concentrations were measured. The relation of the blood oxygen level-dependent (BOLD) signal with plasma glucose and hormone concentrations was assessed by using Pearson's correlation analysis. Results: Ingested macronutrients similarly reduced the BOLD signal in the middle insula, thalamus, parahippocampal cortex, caudate, and lateral OFC. Protein ingestion reduced the BOLD signal in the amygdala more effectively than did fat and glucose ingestion. BOLD signal changes were positively correlated with circulating ghrelin concentrations and were negatively correlated with circulating insulin, CCK, and GLP-1 concentrations. The findings indicate variations in the correlation between brain activation and plasma hormone concentrations after ingestion of different macronutrients. Conclusions: The middle insula, thalamus, parahippocampal cortex, caudate, and lateral OFC, but not the amygdala, have similar sensitivities, to isocaloric and isovolumetric macronutrient solutions. Differential correlations exist between BOLD signal changes in activated brain regions and postprandial changes in plasma concentrations' of different gut hormones in response to the ingestion of different macronutrients. [ABSTRACT FROM AUTHOR]
- Subjects :
- BRAIN
RADIOGRAPHY
ANALYSIS of variance
APPETITE
BLOOD sugar
STATISTICAL correlation
CARBOHYDRATE content of food
FAT content of food
HORMONES
HUNGER
INSULIN
MAGNETIC resonance imaging
NUTRITIONAL requirements
DIETARY proteins
RESEARCH funding
SATISFACTION
STATISTICS
DATA analysis
GHRELIN
DATA analysis software
DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 00029165
- Volume :
- 96
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- American Journal of Clinical Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 78098028
- Full Text :
- https://doi.org/10.3945/ajcn.112.037440