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Beneficial Effect of Vardenafil on Aortic Stiffness and Wave Reflections.
- Source :
- Journal of Clinical Pharmacology; Aug2012, Vol. 52 Issue 8, p1215-1221, 7p
- Publication Year :
- 2012
-
Abstract
- Although vardenafil is widely prescribed for erectile dysfunction (ED), its effect on arterial function is not defined. Aortic stiffness, aortic pressures, and wave reflections are predictors of cardiovascular risk. The investigators assessed the hypothesis that vardenafil acutely improves aortic stiffness, aortic pressures, and wave reflections in ED patients. Twelve ED patients (mean age 58 ± 9 years) received vardenafil 20 mg in a randomized, placebo-controlled, double-blind, 2-way crossover design. Aortic stiffness was evaluated with carotid–femoral pulse wave velocity (PWV); wave reflections and aortic pressures were evaluated with augmentation index (AIx) and systolic, diastolic, and pulse pressure of the aortic pressure waveform, respectively. PWV, aortic pressures, and AIx were measured at baseline and for 3 hours after vardenafil intake or placebo. PWV decreased significantly (by 0.7 m/s, P = .001), denoting a decrease in aortic stiffness. AIx decreased significantly (by 7%, P = .008), denoting a decreased effect of wave reflections from the periphery. Aortic pressures decreased significantly (all P < .05). Statin use at baseline significantly interacted with the effects of treatment on both PWV and AIx (P = .003 and P < .001, respectively). This study shows, for the first time, that vardenafil has a favorable acute effect on aortic stiffness and wave reflection in ED patients. [ABSTRACT FROM PUBLISHER]
- Subjects :
- ANALYSIS of variance
AORTA
ARTERIES
BLOOD pressure
CROSSOVER trials
HEART beat
IMPOTENCE
STATISTICAL sampling
SCALES (Weighing instruments)
T-test (Statistics)
TIME
TONOMETRY
CYCLIC nucleotide phosphodiesterase inhibitors
STATINS (Cardiovascular agents)
RANDOMIZED controlled trials
WAVE analysis
REPEATED measures design
BLIND experiment
DATA analysis software
DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 00912700
- Volume :
- 52
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of Clinical Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 78166892
- Full Text :
- https://doi.org/10.1177/0091270011413586