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Transforming growth factor-β1 levels in hypertensive patients: association with body mass index and leptin.
- Source :
- American Journal of Hypertension; Sep2002, Vol. 15 Issue 9, p759, 7p
- Publication Year :
- 2002
-
Abstract
- : BackgroundTransforming growth factor-β<subscript>1</subscript> (TGF-β<subscript>1</subscript>) has been demonstrated to be overexpressed in hypertension. Leptin, an adipocyte product, has been shown to play a role in obesity-related hypertension and in vitro studies demonstrated a biologic interaction between leptin and TGF-β<subscript>1</subscript>. Thus, we evaluate a possible in vivo association between TGF-β<subscript>1</subscript>, body mass index (BMI), and leptin circulating levels in hypertensive subjects.: MethodsBlood samples for fasting leptin and TGF-β<subscript>1</subscript>, were evaluated in 29 overweight, 46 obese, and 29 nonobese hypertensive patients before and after a 12-week calorie-restricted diet. Monocyte cultures were used for in vitro experiments.: ResultsTransforming growth factor-β<subscript>1</subscript> was significantly elevated in hypertensive obese patients (n = 46) as compared with TGF-β<subscript>1</subscript> levels of hypertensive patients with normal BMI (n = 29) (8. 9 ± 3 ng/mL v 4.4 ± 2; P < .001). The circulating levels of TGF-β<subscript>1</subscript> were associated with BMI and leptin levels in an univariate analysis (r = 0.59, P < .0001; r = 0.62, P < .0001, respectively) and these associations were still present after stepwise multivariate analysis. Weight loss of 10% produced a parallel decrease in TGF-β<subscript>1</subscript> (from 8.9 ± 3 ng/mL to 5.3 ± 2.8 ng/mL; P < .01) and leptin levels (from 30 ± 24 ng/mL to 17 ± 14; P < .05). In vitro experiments showed that leptin is able to induce a dose-dependent increase in TGF-β<subscript>1</subscript> production and mRNA expression in human monocyte cultures.: ConclusionsOur data indicate that TGF-β<subscript>1</subscript> levels are positively associated with BMI and leptin levels in hypertensive patients and suggest that adipose tissue may be an important determinant of TGF-β<subscript>1</subscript> levels possibly by a leptin-dependent pathway. [Copyright &y& Elsevier]
- Subjects :
- TRANSFORMING growth factors-beta
HYPERTENSION
OBESITY
Subjects
Details
- Language :
- English
- ISSN :
- 08957061
- Volume :
- 15
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- American Journal of Hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 7869612
- Full Text :
- https://doi.org/10.1016/S0895-7061(02)02978-3