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Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T101<FN ID="FN1"><NO>1</NO>The nucleotide sequence of human pp-GalNAc-T10 reported in this paper has been deposited in the DDBJ/EMBL/GenBank databases with accession number AB078145.</FN>
- Source :
- FEBS Letters; Nov2002, Vol. 531 Issue 2, p115, 7p
- Publication Year :
- 2002
-
Abstract
- A novel member of the human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (pp-GalNAc-T) gene family was cloned as a homolog of human pp-GalNAc-T7, and designated pp-GalNAc-T10. pp-GalNAc-T10 transcript was found in the small intestine, stomach, pancreas, ovary, thyroid gland and spleen. In a polypeptide GalNAc-transfer assay, recombinant pp-GalNAc-T10 transferred GalNAc onto a panel of mucin-derived peptide substrates. Furthermore, pp-GalNAc-T10 demonstrated strong transferase activity with glycopeptide substrates. [Copyright &y& Elsevier]
- Subjects :
- MOLECULAR cloning
POLYMERASE chain reaction
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 531
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 7921295
- Full Text :
- https://doi.org/10.1016/S0014-5793(02)03399-9