Comparison of Renal Function after Partial Nephrectomy and Radical Nephrectomy for Renal Cell Carcinoma.

Objective: To investigate the time-dependent changes of estimated glomerular filtration rate (eGFR) after radical ne-phrectomy (RN) and partial nephrectomy (PN) for renal cell carcinoma (RCC) and to determine the risk factors for the new onset of a postoperative eGFR <60 ml/min/1.73 m². Pa-tients and Methods: We assessed the renal function of 253 RCC patients by using the eGFR, and investigated the time-dependent changes of the eGFR after the operation. Regres-sion models were used to determine risk factors for the new onset of an eGFR of <60 ml/min/1.73 m² in 211 patients who had at least one month of postoperative follow-up. Results: From the first postoperative day to the 60th postoperative month the eGFR in the RN group was significantly lowerthan that in the PN group. For patients who had at least 1 month of postoperative follow-up, multivariable analysis revealed that RN (p < 0.001), age (p = 0.028), and maleness (p = 0.013) were risk factors for the postoperative onset of an eGFR <60 ml/min/1.73 m². Conclusions: Renal function after PN was better than that after RN, and RN was a greater risk fac-tor for the postoperative onset of an eGFR <60 ml/min/ 1.73 m². [ABSTRACT FROM AUTHOR]