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Human Immunodeficiency Virus Type-1 (HIV-1) Continues to Evolve in Presence of Broadly Neutralizing Antibodies More than Ten Years after Infection.

Authors :
Chaillon, Antoine
Braibant, Martine
Hué, Stéphane
Bencharif, Samia
Enard, David
Moreau, Alain
Samri, Assia
Agut, Henri
Barin, Francis
Gray, Clive M.
Source :
PLoS ONE; Aug2012, Vol. 7 Issue 8, Special section p1-13, 13p
Publication Year :
2012

Abstract

Background: The evolution of HIV-1 and its immune escape to autologous neutralizing antibodies (Nabs) during the acute/ early phases of infection have been analyzed in depth in many studies. In contrast, little is known about neither the long- term evolution of the virus in patients who developed broadly Nabs (bNabs) or the mechanism of escape in presence of these bNabs. Results: We have studied the viral population infecting a long term non progressor HIV-1 infected patient who had developed broadly neutralizing antibodies toward all tier 2/3 viruses (6 clades) tested, 9 years after infection, and was then followed up over 7 years. The autologous neutralization titers of the sequential sera toward env variants representative of the viral population significantly increased during the follow-up period. The most resistant pseudotyped virus was identified at the last visit suggesting that it represented a late emerging escape variant. We identified 5 amino acids substitutions that appeared associated with escape to broadly neutralizing antibodies. They were V319I/S, R/K355T, R/W429G, Q460E and G/ T463E, in V3, C3 and V5 regions. Conclusion: This study showed that HIV-1 may continue to evolve in presence of both broadly neutralizing antibodies and increasing autologous neutralizing activity more than 10 years post-infection. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
19326203
Volume :
7
Issue :
8
Database :
Complementary Index
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
80435663
Full Text :
https://doi.org/10.1371/journal.pone.0044163