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DNA hypermethylation promotes the low expression of pro-apoptotic BCL2L11 associated with BCR - ABL1 fusion gene of chronic myeloid leukaemia.
- Source :
- British Journal of Haematology; Nov2012, Vol. 159 Issue 3, p373-376, 3p, 1 Diagram, 1 Graph
- Publication Year :
- 2012
-
Abstract
- The article informs about a study based on promoting the low expression of pro-apoptotic BCL2L11 gene associated with BCR-ABL1 fusion gene of chronic myeloid leukemia through DNA hypermethylation. It mentions that polymerase chain reaction and immunoprecipitation methods are used in the study. It adds that DNA methyltransferase (DNMT) 1 recruitment and 5 methylcytosine (5mC) excess was found to be involved in the aberrant DNA methylation at promoter-associated CpG islands of several genes.
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 159
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 82334803
- Full Text :
- https://doi.org/10.1111/bjh.12023