DNA hypermethylation promotes the low expression of pro-apoptotic BCL2L11 associated with BCR - ABL1 fusion gene of chronic myeloid leukaemia.

The article informs about a study based on promoting the low expression of pro-apoptotic BCL2L11 gene associated with BCR-ABL1 fusion gene of chronic myeloid leukemia through DNA hypermethylation. It mentions that polymerase chain reaction and immunoprecipitation methods are used in the study. It adds that DNA methyltransferase (DNMT) 1 recruitment and 5 methylcytosine (5mC) excess was found to be involved in the aberrant DNA methylation at promoter-associated CpG islands of several genes.