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Mortality and Treatment Failure among HIV-Infected Adults in Dar Es Salaam, Tanzania.

Authors :
Chalamilla, Guerino
Hawkins, Claudia
Okuma, James
Spiegelman, Donna
Aveika, Akum
Christian, Beatrice
Koda, Happiness
Kaaya, Sylvia
Mtasiwa, Deo
Fawzi, Wafaie
Source :
JIAPAC: Journal of the International Association of Physicians in AIDS Care; Sep2012, Vol. 11 Issue 5, p296-304, 9p
Publication Year :
2012

Abstract

Objectives: Monitoring antiretroviral treatment (ART) outcomes is essential for assessing the success of HIV care and treatment programs in resource-limited settings (RLS). Methods: Longitudinal analyses of clinical and immunologic parameters in HIV infected adults initiated on ART between November 2004 and June 2008 at Management and Development for Health (MDH)-Presidents Emergency Plan For AIDS Relief PEPFAR supported HIV care and treatment clinics in Tanzania. Results: A total of 12 842 patients were analyzed (65.9% female, median baseline CD4 count, 106 cells/mm3). Significant improvements in immunologic status were observed with an increase in CD4 count to 298 (interquartile range [IQR] 199-416), 372 (256- 490) and 427 (314-580) cells/mm3, at 1, 2, and 3 years, respectively. Overall mortality was 13.1% (1682 of 12 842). Male sex, World Health Organization (WHO) stage III/IV, CD4 <200 cells/mm3, hemoglobin (Hgb) <8.5 g/dL, and stavudine (d4T)-containing regimens were independently associated with early and overall mortality. Conclusions: Closer monitoring of males and patients with advanced HIV disease following ART initiation may improve clinical and immunologic outcomes in these individuals. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15451097
Volume :
11
Issue :
5
Database :
Complementary Index
Journal :
JIAPAC: Journal of the International Association of Physicians in AIDS Care
Publication Type :
Academic Journal
Accession number :
82378495
Full Text :
https://doi.org/10.1177/1545109711406733